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Symbol	Explanation
No symbol	At least one of the keywords must be present Search example: serious adverse event Result: Will contain serious and/or adverse and/or event
+	Leading plus sign indicates that the word must be present Search example: serious +adverse event Result: Will contain adverse and may contain serious and/or event
-	Leading minus sign indicates that the word must not be present Search example: serious adverse -event Result: Will contain serious and/or adverse but won’t contain event
“ ”	Exact phrase must be present Search example: “serious adverse event” Result: Will contain the phrase serious adverse event

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